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Borderlands 4 Mission List: Complete Guide to the Kairos Campaign

Last Updated: October 17, 2025

Borderlands 4 Vault Hunters exploring the planet Kairos.

Gear up, Vault Hunters! Following its explosive launch on September 12, 2025, Borderlands 4 has unleashed a new galaxy of mayhem on the dangerous planet of Kairos. To help you navigate the corporate-controlled chaos and unearth its secrets, we've compiled the definitive, spoiler-light guide to every main story mission.

This comprehensive list breaks down the entire campaign, region by region, so you can track your progress and prepare for the fight ahead.

Mission Structure in Borderlands 4

As with previous titles, Borderlands 4's campaign is divided into a linear series of main story missions that guide you across the diverse biomes of Kairos. These are complemented by a vast number of optional side quests that offer unique rewards, character development, and some of the game's most memorable moments. Our guide focuses exclusively on the main story missions required to complete the central narrative.

Common objectives include:

  • Assassination: Target and eliminate high-value corporate commanders, alien monstrosities, or rival gang leaders.
  • Retrieval: "Liberate" key items, from powerful artifacts to critical intelligence (or a specific type of cheeseburger).
  • Sabotage: Infiltrate enemy strongholds to blow things up, reprogram systems, or generally cause a ruckus.
  • Holdout: Defend a specific location or character against waves of increasingly difficult enemies.
  • Exploration: Chart a path through a new area, often culminating in a massive boss battle.

Complete Main Mission List by Region

The story of Borderlands 4 unfolds across the distinct and hazardous regions of the planet Kairos.

Part 1: The Rust-Cankered Coast

Your adventure begins with a crash landing on the junk-strewn, bandit-infested coastline of Kairos. This introductory region pits you against scavenger gangs and the planet's hostile fauna as you get your bearings and meet the key players in the fight against the ruling corporation.

  • Mission 01: A Hell of a Welcome: Survive your crash, find a weapon, and establish contact with the local resistance.
  • Mission 02: Getting Your Sea Legs: Help the local salvagers power up their town's defenses.
  • Mission 03: Big Fish, Bigger Gun: Hunt a massive local creature that has been terrorizing the coastline.
  • Mission 04: Hostile Takeover: Infiltrate the first major corporate outpost and shut down their coastal shipping operations.
  • Mission 05: All Aboard the Pain Train: Fight your way onto a corporate cargo train to leave the region and push further inland.

Part 2: Glimmer-Fungus Caverns

Leaving the coast behind, you'll delve into a network of stunning, bioluminescent caves. These caverns are not only beautiful but also treacherous, filled with spore-releasing fungi, crystal-armored creatures, and a forgotten research facility with dark secrets.

  • Mission 06: Into the Glow: Navigate the entrance to the caverns and find a guide to lead you through the toxic spores.
  • Mission 07: The Sound of Screams: Investigate strange transmissions emanating from the heart of the cave system.
  • Mission 08: Specimen A-01: Discover an abandoned Eridian research lab and uncover the origins of a terrifying new enemy type.
  • Mission 09: Crystal Clear Sabotage: Destroy the mining drills threatening to collapse the entire cavern network.
  • Mission 10: The Caretaker: Face off against a massive, crystal-infused guardian blocking the path to the surface.

Part 3: The Hyperion Spire

Emerging from the depths, you arrive at the base of the Hyperion Spire, a monument to corporate greed and the central headquarters of the game's primary antagonist. The final act of the game involves a grueling, floor-by-floor ascent through the tower, battling elite security forces and high-tech war machines.

  • Mission 11: Knocking on the Door: Breach the Spire's ground-level security and fight your way into the lobby.
  • Mission 12: Corporate Ladder, Corporate Massacre: Ascend through the administrative levels, disrupting operations and taking out key lieutenants.
  • Mission 13: R&D & D (Research and Destruction): Shut down the Spire's weapons development labs.
  • Mission 14: Hostile Communications: Seize control of the primary broadcast tower to send a message of rebellion across Kairos.
  • Mission 15: Boardroom Blitz: Crash the executive board meeting on the penultimate floor.
  • Mission 16: The Rooftop Garden of Unimaginable Pain: Reach the Apex and confront the final boss in a multi-stage showdown for the fate of the planet.

With this guide, you're now equipped to tackle the main campaign of Borderlands 4. But remember, the story missions are just the beginning. Explore every corner of Kairos, take on every side quest, and gear up for the endgame content that awaits. Good luck out there, Vault Hunter